Movie Monday: Hit Man

In our hotel in Virginia this weekend (we were there for a wedding the next day), we only had access to Netflix and aren't currently watching any TV shows on it, so we chose a new movie I'd heard about: Hit Man. This fun, twisty thriller/rom-com turned out to be very entertaining!

Glen Powell stars as Gary Johnson, a classic mild-mannered professor who lives alone with his two cats, Id and Ego. He teaches philosophy at the University of New Orleans. As a hobby, he has a talent for electronics, so he works part-time for the NOPD, helping them with electronic surveillance. Undercover cop Jasper, played by Austin Amelio, pretends to be a hit man, someone tries to hire him, the police get him on audio (and often, video) with Gary's help, and they arrest the person. One day, Jasper gets suspended from the force just before one of these fake hit man appointments is to occur, and Detective Claudette, played by Retta, asks Gary to come out of the surveillance van and instead take Jasper's place and pretend to be the killer-for-hire. It turns out that quiet, introverted Gary does a great job in the role, and he becomes the new fake hit man for future sting operations. Gary, teaching philosophy to uninterested undergrads in his day job, gets really into making up a different persona to fit each new prospective "client," based on what he thinks they'll expect. He uses wigs, facial hair, different clothes, and even fake teeth, and fully inhabits the character he's pretending to be. His arrest rate speaks for itself. Then, a beautiful woman named Madison, played by Adria Arjona, tries to hire him to kill her husband. It's clear he's been controlling and abusive and Madison is scared, so Gary goes off-script. Instead of letting her clearly state that she wants to pay him to kill her husband (thus ensuring a conviction), Gary talks her out of it and convinces her to run away from him instead. His team is not happy with the outcome. When he met Madison, Gary was pretending to be Ron, an ultra-cool, handsome guy. They meet up again and are very attracted to each other. Though Gary knows it's wrong, he really likes Madison, and they begin seeing each other. Besides, he kind of likes being Ron. How can this relationship end well, when it's based on a lie? And how long can Gary keep his colleagues from finding out?

Crazy as it sounds, this movie is based on a real-life man named Gary Johnson who helped Houston police convict many people of hiring a contract killer over more than a decade. Of course, writer and director Richard Linklater (of Boyhood and the Before trilogy) gave the underlying story the Hollywood treatment here, with a lot of laughs, a hot romance, and some unexpected twists that didn't happen in real life. It's an intriguing premise for a movie, and Glen Powell is outstanding in the leading role, somehow easily transforming from nerdy teacher to slick criminal with dozens of different personas. This movie is filled with humor, from Gary's many disguises to his wide range of clients (including a teen boy who wants to pay him in video games--really happened!) to the sting operations. It's also very sexy, with Gary fully coming into his own as Ron, with Madison's help. But there is also plenty of suspense and lots of surprising twists, especially after Gary and Madison get involved and are in danger of being found out. It was highly entertaining, and we thoroughly enjoyed it. Lots of fun!

Hit Man is a Netflix original movie and is currently available there.

TV Tuesday: Dark Matter

I absolutely love when a book I enjoyed is adapted into a TV show or movie, so I was incredibly excited to hear that Dark Matter by Blake Crouch (my review at the link) was going to air on Apple TV. This is one of my all-time favorite books, a twisty sci fi thriller, and so far, the TV adaptation, Dark Matter, is living up to its source material.

Jason Desson, played by Joel Edgerton, is happily married to Daniela, played by Jennifer Connelly, and they both adore their teen son, Charlie, played by Oakes Fegley. They live in Chicago, and Jason works as a physics professor at a small, local college. Daniela had dreams of being a professional artist, but she now works to help support their family. In the first episode, Daniela encourages Jason to go to a party at a local bar, honoring his best friend, Ryan (played by Jimmi Simpson), who just won a prestigious science award. From their conversation at the party, it's clear that Jason is just as talented but chose the path he did to support his family more reliably. Ryan asks Jason to join him in a new venture, but it would require moving to California, and Jason turns him down. Walking home, Jason is brooding over the path not taken when he is suddenly grabbed on the street and kidnapped. He's taken to a deserted warehouse by his masked captor and injected with something. The next thing he knows, he's waking up in a place he doesn't recognize, surrounded by people he doesn't know but that know him. They say he's been gone for over a year, and they're glad to see him. Jason finds out that this place has the technology to travel to parallel universes, a concept he understands because he himself did the initial research years ago, before he got married. He realizes that he is somehow in one of those parallel worlds, and he is desperate to get back to his wife and son ... but how?

As with the book, this TV show is based on a mind-blowing concept, that there are infinite worlds and that with every choice made or change in events, another variation splinters off. This isn't fantasy but science fiction, based on quantum mechanics (don't worry--it's all beyond my understanding, too!). Crouch put this fascinating concept to good use in this twisty, gripping, and thought-provoking thriller. My husband and I both loved this fabulous novel, and the TV show hews very closely to the book (much to our delight), probably due to the author being the one who created the show and did much of its writing to adapt it. Blake Crouch is adept at that, having written other TV shows, including Wayward Pines and Good Behavior (also based on his own novels). So, the writing is sharp and engaging. The actors all do a great job here, each portraying the same character in many different worlds, each one the same person but slightly different. And that plot! It's unique, suspenseful, and full of surprises. The cinematography is also outstanding for the small screen, as Jason visits Chicago in world after world (some of them apocalyptic). It's just an all-around outstanding TV show. Apple TV really seems to excel at science fiction shows (like their adaptation of Silo by Hugh Howey, coming back soon for season 2, and For All Mankind, an alternative history of the space program). We are loving this one and look forward to a new episode every week!

Dark Matter is currently airing on Apple TV. We've seen six of the nine episodes and will be watching #7 tonight. I can't wait!

I practically squealed in delight watching this trailer again:

Potential New Treatment for ME/CFS & Long-COVID Shows Promising Results

One of the top ME/CFS specialists, Dr. Kaufman of the Center for Complex Diseases in California, published a paper with a colleague in 2022 about a supplement that has shown stunning results in his ME/CFS and long-COVID patients. The supplement is oxaloacetate, and in an informal "proof of concept" study (i.e. not a placebo-controlled study), his team gave the supplement at various doses to patients with ME/CFS and long-COVID over six weeks and assessed changes in fatigue scores, using a standard scoring guideline. Results showed significant improvement in both groups of patients (22-28% in ME/CFS patients and 47% in long-COVID patients). They clearly saw that higher doses were more effective. You can read the details of their preliminary study here.

They then began a more formal clinical trial, placebo-controlled and over a longer period of time, for ME/CFS patients. That trial is in progress, but Dr. Kaufman reported on stunning interim results at an ME/CFS symposium last November. You can watch his short (14-min) video on YouTube or below:

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He explains that he is mainly a clinician (treating patients), so he keeps the science fairly simple here, and it's an interesting talk. Watch for the results he presents, about halfway through. The trial has so far shown amazing results, not only in reduced fatigue levels but also in patients being able to spend more time upright (sitting or standing), rather than horizontal ... which is, of course, huge.

They are currently recruiting long-COVID patients for a similar trial through the Bateman-Horne Center. You can sign up here.

Other researchers are studying it in ALS and cancer patients, as well.

Of course, I immediately searched to find out if this supplement is available now. It is, but at the doses used in the study (1000 mg twice a day), it is very expensive, about $500 for a month. This is the exact supplement being used in the trials, with the higher dose, and available directly through the manufacturer.

Oxaloacetate is already available commercially through Amazon (and other suppliers, I'm sure), sold as a supplement for anti-aging and PMS support (interesting), but these are a much lower dose, just 250 mg per pill (so you'd have to take 8 pills a day to hit the amount used in the trials). I saw two main brands there, benaGene (looks like the same manufacturer as what was used in the trial) and Jubiliance, each with 30 pills for about $50. But since you'd have to take 8 pills a day to get the most effective dose, a bottle of 30 would only last just under 4 days, and you'd need 8 bottles to last a full month, which would cost $400. And I can't tell from the labels whether these contain the exact same molecule as was used in the trial (which specifies AEO anhydrous enol-oxaloacetate). So, I wouldn't recommend going it on your own just yet (unless you can afford the $500/month for the exact one used in the trial). I plan to wait for these latest study results to be published and hope that maybe the price will come down.

This study presents one of the most promising treatments for ME/CFS and long-COVID we've seen so far! And, while the cost is currently out of reach for many patients, it is currently available, which is pretty amazing. Keep your eye on this one! I'll report any additional news I hear about it.

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